CMap Candidate Details

Structure:
CMap ID: C00854
Pert ID: BRD-A34907681
Compound Name: rutin
Targets: AKR1C3
MoA: Antioxidant; Nitric oxide scavenger; Capillary stabilizing agent
SMILES: CC1OC(OCC2OC(Oc3c(oc4cc(O)cc(O)c4c3=O)c5ccc(O)c(O)c5)C(O)C(O)C2O)C(O)C(O)C1O
InchiKey: IKGXIBQEEMLURG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1688 BRD-A34907681 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.79
2036 BRD-A34907681 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2332 BRD-A34907681 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2754 BRD-A34907681 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41662 BRD-A34907681 A375 10 uM 6 h 0.24 1.01 0.12 0.31 1.08 0.66
41878 BRD-A34907681 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42197 BRD-A34907681 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42542 BRD-A34907681 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.8
42848 BRD-A34907681 HT29 10 uM 6 h 0.22 0.94 0.05 -0.23 -0.78 0.09
43121 BRD-A34907681 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43398 BRD-A34907681 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43712 BRD-A34907681 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44003 BRD-A34907681 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).