CMap Candidate Details

Structure:
CMap ID: C08562
Pert ID: BRD-K19462402
Compound Name: buflomedil
Targets: ADRA1A
MoA: Calcium channel blocker; Adrenergic receptor antagonist
SMILES: COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1
InchiKey: OWYLAEYXIQKAOL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24655 BRD-K19462402 A549 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
25339 BRD-K19462402 VCAP 10 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
121475 BRD-K19462402 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121500 BRD-K19462402 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.44
129397 BRD-K19462402 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129428 BRD-K19462402 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
129462 BRD-K19462402 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
129483 BRD-K19462402 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129513 BRD-K19462402 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).