CMap Candidate Details

Structure:
CMap ID: C08573
Pert ID: BRD-K19507340
Compound Name: megestrol-acetate
Targets: PGR
MoA: DNA inhibitor; Steroidal progestin; Progesterone receptor agonist
SMILES: CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)=O
InchiKey: RQZAXGRLVPAYTJ-GQFGMJRRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6729 BRD-K19507340 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7300 BRD-K19507340 HA1E 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
7633 BRD-K19507340 HCC515 10 uM 6 h -0.26 -1.07 0.26 -0.29 -0.98 0.49
7843 BRD-K19507340 HT29 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
8231 BRD-K19507340 MCF??7.00 10 uM 6 h 0.29 1.21 0.45 -0.28 -0.95 0.41
8353 BRD-K19507340 PC3 10 uM 24 h 0.24 1.02 0.12 -0.37 -1.24 1.35
8652 BRD-K19507340 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
24562 BRD-K19507340 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53012 BRD-K19507340 HEPG2 30 uM 48 h -0.2 -0.85 0.01 0.0 0.0 0.0
53071 BRD-K19507340 MCF10A 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).