CMap Candidate Details

Structure:
CMap ID: C08637
Pert ID: BRD-K19687926
Compound Name: lapatinib
Targets: EGFR; ERBB2
MoA: EGFR inhibitor; ErbB2 inhibitor
SMILES: CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
InchiKey: BCFGMOOMADDAQU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2 BRD-K19687926 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
7 BRD-K19687926 NCIH2073 0.66 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
15 BRD-K19687926 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24 BRD-K19687926 NCIH596 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32 BRD-K19687926 SKBR3 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1195 BRD-K19687926 PC3 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
1236 BRD-K19687926 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1311 BRD-K19687926 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
1407 BRD-K19687926 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34060 BRD-K19687926 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34576 BRD-K19687926 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35746 BRD-K19687926 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36219 BRD-K19687926 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36513 BRD-K19687926 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36787 BRD-K19687926 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87289 BRD-K19687926 BJAB 2.5 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
87365 BRD-K19687926 HBL1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87415 BRD-K19687926 K562 10 uM 24 h -0.25 -1.05 0.24 -0.44 -1.48 15.35
87463 BRD-K19687926 KMS34 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
87506 BRD-K19687926 MINO 10 uM 3 h -0.19 -0.77 0.0 -0.4 -1.36 2.02
87567 BRD-K19687926 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87617 BRD-K19687926 OCILY10 10 uM 24 h 0.18 0.73 0.0 -0.31 -1.04 0.67
87668 BRD-K19687926 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.08
87719 BRD-K19687926 OCILY3 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87766 BRD-K19687926 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
87822 BRD-K19687926 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87852 BRD-K19687926 TMD8 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
90798 BRD-K19687926 HPTEC 100 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91032 BRD-K19687926 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
91538 BRD-K19687926 BT20 10 uM 6 h 0.29 1.23 0.5 0.0 0.0 0.0
92567 BRD-K19687926 HME1 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92593 BRD-K19687926 HS578T 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
92640 BRD-K19687926 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92701 BRD-K19687926 LNCAP 3.33 uM 3 h 0.25 1.04 0.16 -0.32 -1.09 0.82
92749 BRD-K19687926 MCF10A 1.11 uM 3 h -0.21 -0.88 0.03 0.0 0.0 0.0
92779 BRD-K19687926 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120856 BRD-K19687926 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120902 BRD-K19687926 HA1E 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
120936 BRD-K19687926 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120995 BRD-K19687926 HELA 10 uM 3 h 0.0 0.0 0.0 -0.32 -1.07 0.76
121094 BRD-K19687926 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).