CMap Candidate Details

Structure:
CMap ID: C00087
Pert ID: BRD-A03249105
Compound Name: ICI-182780
Targets: ESR1
MoA: Estrogen receptor antagonist
SMILES: C[C@]12CC[C@H]3C([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31
InchiKey: VWUXBMIQPBEWFH-LQKBAPIOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95319 BRD-A03249105 A549 10 uM 48 h 0.0 0.0 0.0 -0.34 -1.14 1.02
95352 BRD-A03249105 MCF??7.00 10 uM 24 h -0.2 -0.83 0.0 -0.39 -1.3 1.68
95402 BRD-A03249105 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122842 BRD-A03249105 A375 0.125 uM 24 h -0.31 -1.31 0.82 0.33 1.15 0.89
122868 BRD-A03249105 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122918 BRD-A03249105 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122952 BRD-A03249105 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122992 BRD-A03249105 HT29 1.11 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
123043 BRD-A03249105 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
123133 BRD-A03249105 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
123156 BRD-A03249105 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123205 BRD-A03249105 THP1 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
131380 BRD-A03249105 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131415 BRD-A03249105 MCF10A 0.01 uM 24 h -0.23 -0.94 0.08 0.37 1.31 1.59
131513 BRD-A03249105 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).