CMap Candidate Details

Structure:
CMap ID: C08777
Pert ID: BRD-K20079257
Compound Name: rufinamide
Targets: SCN1A; SCN3A; SCN9A
MoA: Voltage-gated sodium channel blocker
SMILES: NC(=O)c1cn(Cc2c(F)cccc2F)nn1
InchiKey: POGQSBRIGCQNEG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121407 BRD-K20079257 HELA 0.04 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
121511 BRD-K20079257 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129405 BRD-K20079257 A375 0.01 uM 24 h 0.26 1.09 0.23 0.35 1.25 1.28
129435 BRD-K20079257 HA1E 0.01 uM 24 h 0.18 0.76 0.0 -0.31 -1.03 0.63
129491 BRD-K20079257 HT29 0.25 uM 24 h 0.23 0.98 0.09 -0.23 -0.79 0.1
129520 BRD-K20079257 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129554 BRD-K20079257 PC3 0.01 uM 24 h 0.23 0.95 0.07 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).