CMap Candidate Details

Structure:
CMap ID: C00088
Pert ID: BRD-A03323675
Compound Name: ritonavir
Targets: CYP1A2; CYP3A7; CYP2B6; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2E1; CYP3A4; CYP3A5
MoA: HIV protease inhibitor
SMILES: CC(C)C(NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)NC(CC(O)C(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
InchiKey: NCDNCNXCDXHOMX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49749 BRD-A03323675 A375 10 uM 6 h -0.36 -1.52 1.43 0.0 0.0 0.0
49927 BRD-A03323675 A549 10 uM 6 h 0.24 0.98 0.09 0.33 1.18 0.98
50089 BRD-A03323675 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50444 BRD-A03323675 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50708 BRD-A03323675 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50796 BRD-A03323675 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51086 BRD-A03323675 VCAP 10 uM 6 h 0.0 0.0 0.0 0.35 1.22 1.19
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).