CMap Candidate Details

Structure:
CMap ID: C00880
Pert ID: BRD-A35869383
Compound Name: ibrutinib
Targets: BTK
MoA: BTK inhibitor
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
InchiKey: XYFPWWZEPKGCCK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1164 BRD-A35869383 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
1201 BRD-A35869383 PC3 10 uM 24 h -0.23 -0.95 0.09 -0.42 -1.41 2.02
1232 BRD-A35869383 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1329 BRD-A35869383 U2OS 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
91786 BRD-A35869383 HS578T 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91923 BRD-A35869383 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
92867 BRD-A35869383 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92931 BRD-A35869383 ASC 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.08
92994 BRD-A35869383 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93040 BRD-A35869383 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
93082 BRD-A35869383 HEK293 10 uM 24 h 0.0 0.0 0.0 0.28 0.97 0.36
93125 BRD-A35869383 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
93170 BRD-A35869383 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93220 BRD-A35869383 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93275 BRD-A35869383 JURKAT 10 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
93314 BRD-A35869383 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93356 BRD-A35869383 MDAMB231 10 uM 24 h 0.22 0.91 0.04 0.37 1.33 1.72
93394 BRD-A35869383 NPC 10 uM 24 h -0.18 -0.73 0.0 0.28 1.0 0.42
93484 BRD-A35869383 SKL 1.11 uM 24 h 0.2 0.83 0.0 0.23 0.82 0.1
93542 BRD-A35869383 THP1 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
93582 BRD-A35869383 YAPC 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).