CMap Candidate Details

Structure:
CMap ID: C00089
Pert ID: BRD-A03359064
Compound Name: ICI-89406
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: OC(CNCCNC(=O)Nc1ccccc1)COc1ccccc1C#N
InchiKey: HTLWRKRZKFAAAH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1473 BRD-A03359064 HA1E 10 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
1802 BRD-A03359064 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.6 0.0
2311 BRD-A03359064 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2614 BRD-A03359064 VCAP 10 uM 24 h 0.27 1.13 0.29 -0.28 -0.93 0.34
41639 BRD-A03359064 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41994 BRD-A03359064 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42164 BRD-A03359064 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42510 BRD-A03359064 HEPG2 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
42820 BRD-A03359064 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43102 BRD-A03359064 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43367 BRD-A03359064 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
43684 BRD-A03359064 PHH 10 uM 24 h -0.19 -0.78 0.0 -0.27 -0.91 0.31
43983 BRD-A03359064 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).