CMap Candidate Details

Structure:
CMap ID: C08959
Pert ID: BRD-K20696416
Compound Name: NVP-AEW541
Targets: IGF1R
MoA: IGF-1 inhibitor
SMILES: C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
InchiKey: AECDBHGVIIRMOI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91987 BRD-K20696416 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92013 BRD-K20696416 BT20 10 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
92061 BRD-K20696416 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92091 BRD-K20696416 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92157 BRD-K20696416 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.3 1.05 0.56
92183 BRD-K20696416 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92210 BRD-K20696416 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92250 BRD-K20696416 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92286 BRD-K20696416 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92332 BRD-K20696416 PC3 10 uM 24 h -0.18 -0.76 0.0 0.3 1.06 0.59
92361 BRD-K20696416 SKBR3 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).