CMap Candidate Details

Structure:
CMap ID: C00897
Pert ID: BRD-A36318220
Compound Name: necrostatin-1
Targets: RIPK1
MoA: RIPK inhibitor
SMILES: CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
InchiKey: TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Compound Aliases: NECROSTATIN-1

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8871 BRD-A36318220 A375 150 uM 24 h 0.29 1.23 0.49 -0.22 -0.75 0.06
9143 BRD-A36318220 A549 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9288 BRD-A36318220 AGS 150 uM 6 h 0.22 0.93 0.05 0.0 0.0 0.0
9902 BRD-A36318220 HA1E 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10150 BRD-A36318220 HCC515 150 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
10397 BRD-A36318220 HCT116 150 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.62
11159 BRD-A36318220 MCF??7.00 150 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
11338 BRD-A36318220 NCIH2073 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11653 BRD-A36318220 NCIH508 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11910 BRD-A36318220 NCIH596 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12206 BRD-A36318220 NOMO1 150 uM 6 h -0.25 -1.05 0.24 -0.25 -0.84 0.18
12469 BRD-A36318220 PC3 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12664 BRD-A36318220 SW480 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13144 BRD-A36318220 U937 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13534 BRD-A36318220 VCAP 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37487 BRD-A36318220 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38337 BRD-A36318220 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38851 BRD-A36318220 SKB 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
117156 BRD-A36318220 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117200 BRD-A36318220 HT29 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).