CMap Candidate Details

Structure:
CMap ID: C00903
Pert ID: BRD-A36630025
Compound Name: SN-38
Targets: TOP1
MoA: Topoisomerase inhibitor
SMILES: CCc1c2Cn3c(cc4c(COC(=O)C4(O)CC)c3=O)-c2nc5ccc(O)cc15
InchiKey: FJHBVJOVLFPMQE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8872 BRD-A36630025 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9289 BRD-A36630025 AGS 0.37 uM 6 h -0.26 -1.07 0.28 0.0 0.0 0.0
9591 BRD-A36630025 H1299 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10009 BRD-A36630025 HA1E 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10214 BRD-A36630025 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10398 BRD-A36630025 HCT116 0.37 uM 6 h -0.33 -1.36 1.08 0.0 0.0 0.0
10665 BRD-A36630025 HEPG2 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11102 BRD-A36630025 HT29 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11339 BRD-A36630025 NCIH2073 0.37 uM 6 h -0.2 -0.84 0.01 0.0 0.0 0.0
11654 BRD-A36630025 NCIH508 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11911 BRD-A36630025 NCIH596 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12207 BRD-A36630025 NOMO1 0.37 uM 6 h -0.22 -0.9 0.05 -0.35 -1.19 1.15
12582 BRD-A36630025 PC3 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13066 BRD-A36630025 THP1 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13145 BRD-A36630025 U937 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13422 BRD-A36630025 VCAP 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90537 BRD-A36630025 A549 0.37 uM 6 h -0.18 -0.76 0.0 0.0 0.0 0.0
90545 BRD-A36630025 MCF??7.00 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96051 BRD-A36630025 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).