CMap Candidate Details

Structure:
CMap ID: C09170
Pert ID: BRD-K21396683
Compound Name: marimastat
Targets: MMP1; MMP2; MMP7
MoA: Matrix metalloprotease inhibitor
SMILES: CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
InchiKey: OCSMOTCMPXTDND-OUAUKWLOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120944 BRD-K21396683 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121013 BRD-K21396683 HT29 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
121036 BRD-K21396683 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121102 BRD-K21396683 YAPC 0.125 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
129094 BRD-K21396683 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129111 BRD-K21396683 A549 2.22 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
129130 BRD-K21396683 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129148 BRD-K21396683 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129218 BRD-K21396683 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).