CMap Candidate Details

Structure:
CMap ID: C09189
Pert ID: BRD-K21450440
Compound Name: benzthiazide
Targets: SLC12A3; CA2
MoA: Carbonic anhydrase inhibitor
SMILES: NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O
InchiKey: NDTSRXAMMQDVSW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5594 BRD-K21450440 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6338 BRD-K21450440 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37612 BRD-K21450440 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37880 BRD-K21450440 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38442 BRD-K21450440 NPC 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
38923 BRD-K21450440 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99743 BRD-K21450440 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120859 BRD-K21450440 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120905 BRD-K21450440 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120942 BRD-K21450440 HEK293 1.11 uM 24 h -0.22 -0.93 0.07 0.21 0.76 0.05
120999 BRD-K21450440 HELA 0.125 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121034 BRD-K21450440 MCF??7.00 0.37 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
121071 BRD-K21450440 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
121100 BRD-K21450440 YAPC 0.125 uM 24 h -0.34 -1.43 1.43 0.0 0.0 0.0
129110 BRD-K21450440 A549 0.74 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
129186 BRD-K21450440 HT29 0.74 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).