CMap Candidate Details

Structure:
CMap ID: C00925
Pert ID: BRD-A37704979
Compound Name: SB-203580
Targets: MAPK14; MAPK11
MoA: P38 MAPK inhibitor
SMILES: CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
InchiKey: CDMGBJANTYXAIV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2805 BRD-A37704979 HA1E 10 uM 24 h 0.26 1.1 0.24 -0.3 -1.0 0.55
3682 BRD-A37704979 VCAP 10 uM 24 h -0.21 -0.89 0.04 0.0 0.0 0.0
42544 BRD-A37704979 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43713 BRD-A37704979 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44004 BRD-A37704979 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91787 BRD-A37704979 HS578T 0.08 uM 6 h 0.24 1.02 0.13 0.0 0.0 0.0
91906 BRD-A37704979 MDAMB231 0.37 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
91924 BRD-A37704979 SKBR3 2.22 uM 24 h 0.2 0.84 0.0 -0.33 -1.11 0.92
94478 BRD-A37704979 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
94545 BRD-A37704979 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94636 BRD-A37704979 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94687 BRD-A37704979 HELA 1.11 uM 24 h 0.23 0.97 0.08 -0.28 -0.93 0.35
94739 BRD-A37704979 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94832 BRD-A37704979 HUVEC 3.33 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
94885 BRD-A37704979 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94931 BRD-A37704979 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
94972 BRD-A37704979 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95011 BRD-A37704979 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
95074 BRD-A37704979 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95115 BRD-A37704979 PC3 10 uM 24 h -0.19 -0.8 0.0 0.31 1.1 0.7
95158 BRD-A37704979 SHSY5Y 10 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
95206 BRD-A37704979 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95268 BRD-A37704979 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116278 BRD-A37704979 A375 0.125 uM 24 h -0.31 -1.29 0.79 0.0 0.0 0.0
116324 BRD-A37704979 A549 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
116409 BRD-A37704979 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116510 BRD-A37704979 HT29 10 uM 24 h -0.23 -0.98 0.11 0.3 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).