CMap Candidate Details

Structure:
CMap ID: C09290
Pert ID: BRD-K21733600
Compound Name: rofecoxib
Targets: PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
InchiKey: RZJQGNCSTQAWON-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5192 BRD-K21733600 A375 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.19
6529 BRD-K21733600 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37614 BRD-K21733600 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38444 BRD-K21733600 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
38924 BRD-K21733600 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51926 BRD-K21733600 PC3 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
91041 BRD-K21733600 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99748 BRD-K21733600 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116687 BRD-K21733600 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116727 BRD-K21733600 HA1E 0.37 uM 24 h 0.18 0.74 0.0 0.25 0.89 0.2
116770 BRD-K21733600 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116818 BRD-K21733600 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116861 BRD-K21733600 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116911 BRD-K21733600 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).