CMap Candidate Details

Structure:
CMap ID: C00930
Pert ID: BRD-A37817666
Compound Name: picrotoxin
Targets: GABRA1; GABRR1; GLRA2; GLRA3
MoA: GABA receptor antagonist
SMILES: CC(=C)[C@H]1[C@H]2OC(=O)C1[C@]3(O)CC4O[C@]45C(=O)O[C@H]2[C@@]53C
InchiKey: PIMZUZSSNYHVCU-IQPPENEWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4168 BRD-A37817666 HA1E 10 uM 6 h 0.19 0.79 0.0 0.23 0.8 0.08
4301 BRD-A37817666 HCC515 10 uM 24 h 0.33 1.36 0.97 0.26 0.94 0.28
4616 BRD-A37817666 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4993 BRD-A37817666 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37069 BRD-A37817666 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37231 BRD-A37817666 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37489 BRD-A37817666 ASC 10 uM 24 h 0.18 0.76 0.0 -0.26 -0.86 0.22
37812 BRD-A37817666 HEPG2 10 uM 6 h -0.26 -1.08 0.29 -0.2 -0.67 0.02
38007 BRD-A37817666 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38249 BRD-A37817666 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38339 BRD-A37817666 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
38631 BRD-A37817666 PHH 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).