CMap Candidate Details

Structure:
CMap ID: C00932
Pert ID: BRD-A37837077
Compound Name: cyclazosin
Targets: ADRA1B
MoA: Adrenergic receptor antagonist
SMILES: COc1cc2nc(nc(N)c2cc1OC)N1CCN(C2CCCCC12)C(=O)c1ccco1
InchiKey: XBRXTUGRUXGBPX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33542 BRD-A37837077 A375 10 uM 6 h 0.22 0.91 0.03 0.0 0.0 0.0
33987 BRD-A37837077 ASC 10 uM 24 h 0.26 1.07 0.2 0.29 1.01 0.45
34267 BRD-A37837077 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34501 BRD-A37837077 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
34772 BRD-A37837077 HEPG2 10 uM 6 h 0.24 1.02 0.13 0.0 0.0 0.0
35046 BRD-A37837077 HT29 10 uM 6 h 0.24 0.99 0.1 0.0 0.0 0.0
35271 BRD-A37837077 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35681 BRD-A37837077 NPC 10 uM 24 h 0.24 0.99 0.1 -0.36 -1.22 1.24
36042 BRD-A37837077 PC3 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
36145 BRD-A37837077 PHH 10 uM 24 h 0.22 0.92 0.04 -0.31 -1.04 0.67
36439 BRD-A37837077 SKB 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
36929 BRD-A37837077 VCAP 10 uM 6 h 0.0 0.0 0.0 0.34 1.22 1.15
96080 BRD-A37837077 A549 10 uM 24 h -0.27 -1.12 0.39 -0.46 -1.55 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).