CMap Candidate Details

Structure:
CMap ID: C00935
Pert ID: BRD-A37959677
Compound Name: estrone
Targets: ESR1
MoA: Estrogen receptor agonist
SMILES: C[C@]12CCC3C(CCc4cc(O)ccc34)C1CCC2=O
InchiKey: DNXHEGUUPJUMQT-GUZDXLFXSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6927 BRD-A37959677 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7531 BRD-A37959677 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8573 BRD-A37959677 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123225 BRD-A37959677 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123271 BRD-A37959677 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
123305 BRD-A37959677 HELA 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
123360 BRD-A37959677 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123391 BRD-A37959677 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
123413 BRD-A37959677 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123449 BRD-A37959677 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123483 BRD-A37959677 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131614 BRD-A37959677 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131678 BRD-A37959677 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
131707 BRD-A37959677 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131760 BRD-A37959677 JURKAT 0.03 uM 24 h 0.26 1.09 0.22 -0.28 -0.96 0.43
131844 BRD-A37959677 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).