CMap Candidate Details

Structure:
CMap ID: C00936
Pert ID: BRD-A38030642
Compound Name: cyclosporin-a
Targets: PPIA; PPP3CA
MoA: Calcineurin inhibitor
SMILES: CCC1NC(=O)C([C@H](O)[C@H](C)C/C=C/C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InchiKey: PMATZTZNYRCHOR-NFOUMSERSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1493 BRD-A38030642 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
2273 BRD-A38030642 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
8873 BRD-A38030642 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9290 BRD-A38030642 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9592 BRD-A38030642 H1299 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.78
10162 BRD-A38030642 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
10399 BRD-A38030642 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10666 BRD-A38030642 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11170 BRD-A38030642 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
11340 BRD-A38030642 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11912 BRD-A38030642 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12665 BRD-A38030642 SW480 10 uM 6 h 0.25 1.05 0.17 0.0 0.0 0.0
13003 BRD-A38030642 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13146 BRD-A38030642 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13535 BRD-A38030642 VCAP 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.54
42009 BRD-A38030642 A549 10 uM 6 h 0.0 0.0 0.0 -0.43 -1.46 15.35
42199 BRD-A38030642 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42850 BRD-A38030642 HT29 10 uM 6 h 0.0 0.0 0.0 -0.44 -1.47 15.35
43400 BRD-A38030642 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43714 BRD-A38030642 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44005 BRD-A38030642 SKB 10 uM 24 h 0.24 0.99 0.1 -0.37 -1.24 1.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).