CMap Candidate Details

Structure:
CMap ID: C09371
Pert ID: BRD-K22010301
Compound Name: JLK-6
Targets: PSEN1
MoA: Anti-amyloidogenic agent; Gamma secretase inhibitor
SMILES: COc1oc(=O)c2cc(N)ccc2c1Cl
InchiKey: AMDGKLWVCUXONP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2851 BRD-K22010301 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3345 BRD-K22010301 HCC515 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.19
3475 BRD-K22010301 PC3 10 uM 24 h -0.22 -0.92 0.06 -0.35 -1.18 1.15
3750 BRD-K22010301 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39103 BRD-K22010301 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39433 BRD-K22010301 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39649 BRD-K22010301 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39965 BRD-K22010301 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40242 BRD-K22010301 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.19
40599 BRD-K22010301 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40771 BRD-K22010301 NEU 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
41072 BRD-K22010301 NPC 10 uM 24 h 0.26 1.1 0.24 -0.23 -0.76 0.07
41403 BRD-K22010301 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).