CMap Candidate Details

Structure:
CMap ID: C09376
Pert ID: BRD-K22031190
Compound Name: diflunisal
Targets: PTGS1; PTGS2
MoA: Prostanoid receptor antagonist
SMILES: OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
InchiKey: HUPFGZXOMWLGNK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5762 BRD-K22031190 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.25
5894 BRD-K22031190 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42325 BRD-K22031190 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43516 BRD-K22031190 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
43814 BRD-K22031190 PHH 10 uM 24 h 0.22 0.93 0.05 -0.24 -0.8 0.11
51136 BRD-K22031190 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91243 BRD-K22031190 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
120861 BRD-K22031190 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120886 BRD-K22031190 A549 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
120947 BRD-K22031190 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
121015 BRD-K22031190 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121039 BRD-K22031190 MCF??7.00 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
121105 BRD-K22031190 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129132 BRD-K22031190 HA1E 2.22 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
129150 BRD-K22031190 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129219 BRD-K22031190 PC3 0.74 uM 24 h 0.22 0.94 0.06 -0.28 -0.96 0.42
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).