CMap Candidate Details

Structure:
CMap ID: C00094
Pert ID: BRD-A03623303
Compound Name: metoprolol
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: COCCc1ccc(OCC(O)CNC(C)C)cc1
InchiKey: IUBSYMUCCVWXPE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3308 BRD-A03623303 HCC515 10 uM 6 h -0.29 -1.19 0.53 -0.27 -0.91 0.3
3662 BRD-A03623303 VCAP 10 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
44741 BRD-A03623303 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45065 BRD-A03623303 HEPG2 10 uM 6 h -0.25 -1.04 0.22 0.0 0.0 0.0
45862 BRD-A03623303 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
46174 BRD-A03623303 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46489 BRD-A03623303 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91224 BRD-A03623303 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.33 1.16 0.91
122665 BRD-A03623303 HT29 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.27
122692 BRD-A03623303 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
130853 BRD-A03623303 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130878 BRD-A03623303 A549 0.01 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
130895 BRD-A03623303 HA1E 0.03 uM 24 h 0.3 1.23 0.5 0.22 0.78 0.07
130925 BRD-A03623303 HEK293 0.01 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
130945 BRD-A03623303 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131013 BRD-A03623303 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.19 0.69 0.01
131067 BRD-A03623303 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131099 BRD-A03623303 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
131134 BRD-A03623303 PC3 0.03 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
131163 BRD-A03623303 YAPC 0.01 uM 24 h 0.23 0.94 0.06 0.3 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).