CMap Candidate Details

Structure:
CMap ID: C09406
Pert ID: BRD-K22134346
Compound Name: simvastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
InchiKey: RYMZZMVNJRMUDD-HGQWONQESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1400 BRD-K22134346 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1417 BRD-K22134346 NPC 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5193 BRD-K22134346 A375 10 uM 6 h -0.22 -0.91 0.05 0.33 1.16 0.91
5438 BRD-K22134346 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5595 BRD-K22134346 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6171 BRD-K22134346 PC3 10 uM 24 h 0.16 0.66 0.0 -0.21 -0.72 0.04
9386 BRD-K22134346 AGS 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
10483 BRD-K22134346 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.93 0.35
11448 BRD-K22134346 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12013 BRD-K22134346 NCIH596 10 uM 6 h 0.19 0.77 0.0 -0.26 -0.87 0.23
12289 BRD-K22134346 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
12760 BRD-K22134346 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13240 BRD-K22134346 U937 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.07
13602 BRD-K22134346 VCAP 10 uM 6 h -0.17 -0.73 0.0 0.25 0.87 0.17
37616 BRD-K22134346 ASC 10 uM 24 h -0.28 -1.15 0.44 0.22 0.77 0.06
38190 BRD-K22134346 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
38926 BRD-K22134346 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53390 BRD-K22134346 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53571 BRD-K22134346 HUH7 10 uM 6 h 0.3 1.26 0.58 0.32 1.14 0.87
53650 BRD-K22134346 PHH 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
98356 BRD-K22134346 NEU 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
116195 BRD-K22134346 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120890 BRD-K22134346 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120966 BRD-K22134346 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
120989 BRD-K22134346 HELA 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
121123 BRD-K22134346 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).