CMap Candidate Details

Structure:
CMap ID: C09482
Pert ID: BRD-K22385716
Compound Name: LY-303511
Targets: BRD4; BRD2; BRD3
MoA: PI3K inhibitor; Casein kinase inhibitor
SMILES: O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
InchiKey: NGAGMBNBKCDCDJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2852 BRD-K22385716 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
3162 BRD-K22385716 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3476 BRD-K22385716 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3751 BRD-K22385716 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44341 BRD-K22385716 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.47
44685 BRD-K22385716 A549 10 uM 6 h 0.0 0.0 0.0 -0.44 -1.49 15.35
44899 BRD-K22385716 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45202 BRD-K22385716 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45468 BRD-K22385716 HT29 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
45671 BRD-K22385716 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46017 BRD-K22385716 NPC 10 uM 24 h 0.21 0.88 0.01 -0.39 -1.3 1.61
46335 BRD-K22385716 PHH 10 uM 24 h 0.31 1.31 0.73 -0.23 -0.77 0.08
46652 BRD-K22385716 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97303 BRD-K22385716 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99753 BRD-K22385716 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).