CMap Candidate Details

Structure:
CMap ID: C00951
Pert ID: BRD-A38749782
Compound Name: fludrocortisone-acetate
Targets: NR3C2
MoA: Glucocorticoid receptor agonist; Mineralocorticoid receptor agonist
SMILES: CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
InchiKey: SYWHXTATXSMDSB-JORUCDAYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7071 BRD-A38749782 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7224 BRD-A38749782 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
7532 BRD-A38749782 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.38 2.02
7945 BRD-A38749782 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8286 BRD-A38749782 MCF??7.00 10 uM 6 h -0.25 -1.04 0.21 -0.28 -0.94 0.38
8753 BRD-A38749782 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95979 BRD-A38749782 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96294 BRD-A38749782 A375 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.26
96367 BRD-A38749782 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).