CMap Candidate Details

Structure:
CMap ID: C09617
Pert ID: BRD-K22822991
Compound Name: odanacatib
Targets: CTSK
MoA: Cathepsin inhibitor
SMILES: CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N
InchiKey: FWIVDMJALNEADT-SFTDATJTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120953 BRD-K22822991 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121041 BRD-K22822991 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121075 BRD-K22822991 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121109 BRD-K22822991 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129097 BRD-K22822991 A375 0.25 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
129115 BRD-K22822991 A549 2.22 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
129135 BRD-K22822991 HA1E 0.74 uM 24 h -0.26 -1.08 0.29 -0.29 -0.97 0.45
129152 BRD-K22822991 HELA 0.25 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
129189 BRD-K22822991 HT29 0.74 uM 24 h 0.22 0.93 0.05 -0.21 -0.71 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).