CMap Candidate Details

Structure:
CMap ID: C09719
Pert ID: BRD-K23190681
Compound Name: AV-412
Targets: EGFR; ERBB2
MoA: Receptor tyrosine protein kinase inhibitor
SMILES: CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
InchiKey: ZAJXXUDARPGGOC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121425 BRD-K23190681 HELA 3.33 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
121449 BRD-K23190681 HT29 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
121469 BRD-K23190681 MCF??7.00 3.33 uM 24 h -0.2 -0.82 0.0 -0.27 -0.9 0.29
121539 BRD-K23190681 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129416 BRD-K23190681 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129453 BRD-K23190681 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129566 BRD-K23190681 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).