CMap Candidate Details

Structure:
CMap ID: C09721
Pert ID: BRD-K23192422
Compound Name: lestaurtinib
Targets: FLT3; NTRK1
MoA: JAK inhibitor; FLT3 inhibitor; Growth factor receptor inhibitor
SMILES: C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13
InchiKey: UIARLYUEJFELEN-DMVVYWCZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33677 BRD-K23192422 A375 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.18
33895 BRD-K23192422 A549 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.89 0.26
34065 BRD-K23192422 ASC 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
34331 BRD-K23192422 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34581 BRD-K23192422 HCC515 10 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
34849 BRD-K23192422 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35113 BRD-K23192422 HT29 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.75
35452 BRD-K23192422 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35549 BRD-K23192422 NEU 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
35750 BRD-K23192422 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35941 BRD-K23192422 PC3 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
36224 BRD-K23192422 PHH 10 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
36518 BRD-K23192422 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36957 BRD-K23192422 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
97705 BRD-K23192422 NKDBA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).