CMap Candidate Details

Structure:
CMap ID: C09778
Pert ID: BRD-K23383398
Compound Name: T-0901317
Targets: NR1H3; NR1H2
MoA: LXR agonist; ROR inverse agonist; ABC transporter expression enhancer
SMILES: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
InchiKey: SGIWFELWJPNFDH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2998 BRD-K23383398 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3163 BRD-K23383398 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.12
22117 BRD-K23383398 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
23010 BRD-K23383398 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23315 BRD-K23383398 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23832 BRD-K23383398 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24135 BRD-K23383398 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42327 BRD-K23383398 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43170 BRD-K23383398 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43518 BRD-K23383398 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43816 BRD-K23383398 PHH 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.18
44090 BRD-K23383398 SKB 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
99760 BRD-K23383398 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).