CMap Candidate Details

Structure:
CMap ID: C09809
Pert ID: BRD-K23478508
Compound Name: digoxin
Targets: ATP1A1
MoA: ATPase inhibitor
SMILES: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4
InchiKey: LTMHDMANZUZIPE-PUGKRICDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1162 BRD-K23478508 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
1191 BRD-K23478508 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1242 BRD-K23478508 A549 0.12 uM 48 h -0.23 -0.96 0.09 -0.45 -1.5 15.35
1346 BRD-K23478508 U2OS 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1564 BRD-K23478508 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
2093 BRD-K23478508 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.47 -1.57 15.65
2785 BRD-K23478508 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41744 BRD-K23478508 A375 10 uM 6 h 0.0 0.0 0.0 -0.53 -1.78 15.65
42328 BRD-K23478508 ASC 10 uM 24 h 0.25 1.05 0.17 -0.36 -1.23 1.25
42655 BRD-K23478508 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.53 -1.77 15.65
42958 BRD-K23478508 HT29 10 uM 6 h 0.0 0.0 0.0 -0.47 -1.6 15.65
43519 BRD-K23478508 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43817 BRD-K23478508 PHH 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.65 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).