CMap Candidate Details

Structure:
CMap ID: C09815
Pert ID: BRD-K23499943
Compound Name: alvespimycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(C)=C/C=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O
InchiKey: KUFRQPKVAWMTJO-TYVPZVKISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120541 BRD-K23499943 A549 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
120587 BRD-K23499943 HA1E 0.04 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
120613 BRD-K23499943 HELA 0.04 uM 24 h -0.32 -1.32 0.82 0.0 0.0 0.0
120642 BRD-K23499943 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120692 BRD-K23499943 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.8
120766 BRD-K23499943 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120798 BRD-K23499943 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128984 BRD-K23499943 A375 0.25 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
129046 BRD-K23499943 MCF??7.00 0.01 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).