CMap Candidate Details

Structure:
CMap ID: C00985
Pert ID: BRD-A39969961
Compound Name: eplerenone
Targets: NR3C2
MoA: Cytochrome P450 inhibitor
SMILES: COC(=O)C1CC2=CC(=O)CCC2(C)C34OC4CC5(C)C(CCC65CCC(=O)O6)C13
InchiKey: JUKPWJGBANNWMW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4017 BRD-A39969961 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4303 BRD-A39969961 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4750 BRD-A39969961 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4851 BRD-A39969961 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37071 BRD-A39969961 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37233 BRD-A39969961 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37491 BRD-A39969961 ASC 10 uM 24 h -0.23 -0.95 0.08 -0.4 -1.33 1.83
37814 BRD-A39969961 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38009 BRD-A39969961 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38269 BRD-A39969961 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38341 BRD-A39969961 NPC 10 uM 24 h 0.22 0.92 0.04 -0.3 -1.01 0.56
38633 BRD-A39969961 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38854 BRD-A39969961 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).