CMap Candidate Details

Structure:
CMap ID: C00990
Pert ID: BRD-A40084411
Compound Name: CGP-12177
Targets: ADRB1; ADRB2; ADRB3
MoA: Adrenergic receptor agonist
SMILES: CC(C)(C)NCC(O)COc1cccc2[nH]c(O)nc12
InchiKey: UMQUQWCJKFOUGV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123234 BRD-A40084411 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123311 BRD-A40084411 HELA 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
123396 BRD-A40084411 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123420 BRD-A40084411 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131549 BRD-A40084411 A549 0.08 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
131584 BRD-A40084411 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
131625 BRD-A40084411 HEK293 2.22 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
131685 BRD-A40084411 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131722 BRD-A40084411 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131775 BRD-A40084411 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131822 BRD-A40084411 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131854 BRD-A40084411 MCF??7.00 0.01 uM 24 h 0.19 0.79 0.0 -0.34 -1.16 1.11
131932 BRD-A40084411 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131951 BRD-A40084411 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).