CMap Candidate Details

Structure:
CMap ID: C09986
Pert ID: BRD-K24023109
Compound Name: diltiazem
Targets: CACNA1C
MoA: Calcium channel blocker
SMILES: COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O
InchiKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2854 BRD-K24023109 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
3165 BRD-K24023109 HCC515 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
3753 BRD-K24023109 VCAP 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
44344 BRD-K24023109 A375 10 uM 6 h 0.2 0.82 0.0 0.24 0.86 0.15
44551 BRD-K24023109 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
44902 BRD-K24023109 ASC 10 uM 24 h 0.27 1.13 0.29 0.35 1.23 1.19
45205 BRD-K24023109 HEPG2 10 uM 6 h 0.17 0.71 0.0 0.3 1.06 0.59
45471 BRD-K24023109 HT29 10 uM 6 h 0.23 0.97 0.08 0.26 0.92 0.26
46020 BRD-K24023109 NPC 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.55
46338 BRD-K24023109 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46655 BRD-K24023109 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.39
51333 BRD-K24023109 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
51448 BRD-K24023109 PC3 10 uM 24 h 0.27 1.12 0.27 -0.25 -0.85 0.19
91031 BRD-K24023109 HUH7 8 uM 72 h 0.3 1.25 0.56 0.22 0.79 0.08
99765 BRD-K24023109 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).