Associated Disease Details
| Disease ID: | I07 |
| DO ID: | 1936 |
| Disease Name: | Arteriosclerosis |
| Definition: | Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35768 |
| Synonyms: | Atherosclerosis; Arteriosclerosis |
| Class: | disease of anatomical entity/cardiovascular system disease/ vascular disease/ artery disease |
| Related Drugs: | Gemcabene |
| Mechanism: | The prevalence of non-alcoholic fatty liver disease (NAFLD) is strongly increasing and may put patients at increased risk for atherosclerotic cardiovascular disease (asCVD). Both disease phenotypes often co-occur, in the case of obesity, insulin resistance, diabetes mellitus type 2, and the metabolic syndrome. |
| Reference (PMIDs): | 31630897 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0622 | DB04838 | approved | small molecule | Cyclandelate | Indication associated | Details |
| R0746 | DB05229 | investigational | small molecule | Beraprost | Indication associated | Details |
| R0932 | DB06152 | approved | small molecule | Nylidrin | Indication associated | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A04442 | 33615471 | J Cell Physiol | A new activator of esterase D decreases blood cholesterol level through ESD/JAB1/ABCA1 pathway. | Details |
| A07584 | 32435522 | World J Gastrointest Pathophysiol | Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad: The overlap of a theory of change and bioinformatics. | Details |
| A08260 | 32184638 | Diabetes Metab Syndr Obes | Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study. | Details |
| A09444 | 31746482 | Aliment Pharmacol Ther | Systematic review: chronic viral hepatitis and metabolic derangement. | Details |
| A09495 | 31721770 | PLoS One | Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease. | Details |
| A11923 | 30680827 | Int J Exp Pathol | Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model. | Details |
| A14142 | 29565984 | PLoS One | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men. | Details |
| A14229 | 29514661 | J Transl Med | Physiological and molecular effects of interleukin-18 administration on the mouse kidney. | Details |
| A17294 | 27860077 | Pathol Int | Critical in vivo roles of histamine and histamine receptor signaling in animal models of metabolic syndrome. | Details |
| A17642 | 27692633 | Clin Investig Arterioscler | Nonalcoholic fatty liver disease, association with cardiovascular disease and treatment. (I). Nonalcoholic fatty liver disease and its association with cardiovascular disease. | Details |
| A17643 | 27692632 | Clin Investig Arterioscler | Nonalcoholic fatty liver disease, association with cardiovascular disease and treatment (II). The treatment of nonalcoholic fatty liver disease. | Details |
| A18071 | 27371101 | J Diabetes | Correlations of non-alcoholic fatty liver disease and serum uric acid with subclinical atherosclerosis in obese Chinese adults. | Details |
| A18951 | 26853695 | Hepatol Res | Association of coronary artery calcification with liver fibrosis in Japanese patients with non-alcoholic fatty liver disease. | Details |
| A19508 | 26516851 | Int J Mol Sci | Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression. | Details |
| A19707 | 26401084 | World J Gastroenterol | Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity. | Details |
| A21512 | 25265201 | Nanotoxicology | Intratracheal exposure to multi-walled carbon nanotubes induces a nonalcoholic steatohepatitis-like phenotype in C57BL/6J mice. | Details |
| A21624 | 25175670 | J Med Case Rep | Oliguric acute kidney injury as a main symptom of bradycardia and arteriosclerosis resolved by pacemaker implantation: a case report. | Details |
| A24186 | 23141876 | Int J Cardiol | Non-alcoholic fatty liver disease and cardiovascular risk. | Details |
| A24620 | 22684314 | Acta Diabetol | Nonalcoholic fatty liver and metabolic syndrome in Italy: results from a multicentric study of the Italian Arteriosclerosis society. | Details |
| A25993 | 21226276 | Nihon Rinsho | [Chronic liver disease and arteriosclerosis]. | Details |