Investigational Drug Details
| Drug ID: | D144 |
| Drug Name: | FTZ |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 16015442 |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | Clc1c(CNc2nc([nH]n2)c2occc2)c(F)ccc1 |
| Structure: |
|
| InChiKey: | AHOHWELPUXLPOF-UHFFFAOYSA-N |
| Molecular Weight: | 292.701 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (ChiCTR1900025938) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0455 | ChiCTR1900025938 | Not applicable | Recruiting | No Results Available | 15/09/2019 | 16 September 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A02606 | 34311531 | Biomed Pharmacother | FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway. | Details |
| A04069 | 33771638 | J Ethnopharmacol | Molecular mechanism of Fufang Zhenzhu Tiaozhi capsule in the treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease based on network pharmacology and validation in minipigs. | Details |
| A13096 | 30140364 | Oxid Med Cell Longev | NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ. | Details |
| A42202 | 35247475 | J Ethnopharmacol | The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against renal injury and inflammation in mice with diabetic kidney disease. | Details |
| A49338 | 35784533 | Front Endocrinol (Lausanne) | Fufang Zhenzhu Tiaozhi Capsule Prevents Intestinal Inflammation and Barrier Disruption in Mice With Non-Alcoholic Steatohepatitis. | Details |
| A51156 | 35447198 | J Ethnopharmacol | The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against atherosclerosis by suppressing EndMT via modulating Akt1/β-catenin signaling pathway. | Details |
| A52062 | 31743877 | Biomed Pharmacother | An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi(FTZ). | Details |