Investigational Drug Details
| Drug ID: | D145 |
| Drug Name: | Fucoidan |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 92023653 |
| CasNo: | 9072-19-9 |
| Repositioning for NAFLD: | No |
| SMILES: | S(=O)(=O)(O[C@H]1[C@@H](O)[C@H](O)[C@H](O[C@H]1C)C)O |
| Structure: |
|
| InChiKey: | NLMDZXKCTWKRSQ-IBISWUOJSA-N |
| Molecular Weight: | 242.249 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial completed (NCT02875392: Altogether, these studies suggest the possibility for future development of fucoxanthin as a one-compound-multiple-target or pro-drug type pharmaceutical or nutraceutical treatment for neurodegenerative disorders.) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0843 | NCT02875392 | Not applicable | Recruiting | No Results Available | 05/08/2016 | 16 December 2017 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A02467 | 34361619 | Molecules | Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. | Details |
| A03953 | 33809062 | Mar Drugs | Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis. | Details |
| A04305 | 33671715 | Molecules | Antioxidant and Antisteatotic Activities of a New Fucoidan Extracted from Ferula hermonis Roots Harvested on Lebanese Mountains. | Details |
| A05728 | 33142346 | Planta Med | Brown-Algae Polysaccharides as Active Constituents against Nonalcoholic Fatty Liver Disease. | Details |
| A14361 | 29447962 | Int J Biol Macromol | Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice. | Details |
| A18431 | 27142736 | J Nutr Biochem | Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoE(shl) mice deficient in apolipoprotein E expression. | Details |
| A19544 | 26498267 | Environ Toxicol Pharmacol | Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. | Details |
| A42814 | 33377648 | Clin Transl Med | Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. | Details |