Investigational Drug Details
| Drug ID: | D150 |
| Drug Name: | Genistein |
| Synonyms: | 4',5,7-trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7,4'-trihydroxyisoflavone; Genistein; Genisteol; Genisterin |
| Type: | Chemical drug |
| DrugBank ID: | DB01645 |
| DrugBank Description: | An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms. It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode. Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women . Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin. |
| PubChem ID: | 5280961 |
| CasNo: | 446-72-0 |
| Repositioning for NAFLD: | No |
| SMILES: | O=c1c2c(occ1c1ccc(cc1)O)cc(cc2O)O |
| Structure: |
|
| InChiKey: | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Molecular Weight: | 270.24 |
| DrugBank Targets: | Estrogen receptor beta; DNA topoisomerase 2-alpha; Protein-tyrosine kinase 2-beta; Nuclear receptor coactivator 1; Estrogen receptor alpha; Nuclear receptor coactivator 2; Steroid hormone receptor ERR2 agonist; Steroid hormone receptor ERR1 agonist; Nucle |
| DrugBank MoA: | Genistein may inhibit cancer cell growth by blocking enzymes required for cell growth. Genistein may decrease cardiovascular risk in postmenopausal women by interacting with the nuclear estrogen receptors to alter the transcription of cell specific genes. In randomized clinical trials, genistein was seen to increase the ratio of nitric oxide to endothelin and improved flow-mediated endothelium dependent vasodilation in healthy postmenopausal women . In addition, genistein may have beneficial effects on glucose metabolism by inhibiting islet tyrosine kinase activity as well as insulin release dependent on glucose and sulfonylurea . |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. |
| Targets: | NCOA1; NCOA2; NR1I2 |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 3 on-going (IRCT201506222480N6) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0873 | IRCT201506222480N6 | Phase 3 | Not Recruiting | No Results Available | 12/07/2015 | 22 February 2018 | Details |
| L0874 | IRCT201312132480N5 | Phase 3 | Not Recruiting | No Results Available | 11/07/2015 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00254 | 35164079 | Molecules | Genistein-Opportunities Related to an Interesting Molecule of Natural Origin. | Details |
| A00869 | 34944525 | Biomolecules | A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. | Details |
| A01383 | 34765514 | J Tradit Complement Med | Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet. | Details |
| A02719 | 34274649 | Environ Pollut | Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens. | Details |
| A03280 | 34062716 | Int J Mol Sci | Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review. | Details |
| A03304 | 34051210 | Biochem Pharmacol | The controversy on the beneficial effect of phytoestrogens in diabetic treatment in postmenopausal women. | Details |
| A03696 | 33899670 | Int J Food Sci Nutr | Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension. | Details |
| A04308 | 33671486 | Molecules | Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis. | Details |
| A05695 | 33152943 | Biomed Pharmacother | The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. | Details |
| A06240 | 32956824 | J Nutr Biochem | Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice. | Details |
| A07473 | 32482167 | BMC Complement Med Ther | Genistein and exercise modulated lipid peroxidation and improved steatohepatitis in ovariectomized rats. | Details |
| A07865 | 32330379 | Cell Physiol Biochem | Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. | Details |
| A09254 | 31816816 | Int J Mol Sci | MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice. | Details |
| A10816 | 31176163 | Biomed Pharmacother | Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD). | Details |
| A11558 | 30841442 | Biomed Pharmacother | Genistein can ameliorate hepatic inflammatory reaction in nonalcoholic steatohepatitis rats. | Details |
| A13758 | 29771124 | J Agric Food Chem | Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway. | Details |
| A13901 | 29702089 | Chem Biol Interact | Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase. | Details |
| A14567 | 29350757 | J Food Sci | Hepatoprotective Effects of Sophoricoside against Fructose-Induced Liver Injury via Regulating Lipid Metabolism, Oxidation, and Inflammation in Mice. | Details |
| A15027 | 29125642 | J Food Sci | Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells. | Details |
| A15930 | 28647291 | Clin Nutr | Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial. | Details |