Investigational Drug Details
| Drug ID: | D151 |
| Drug Name: | Ginger |
| Synonyms: | zingiber officinale |
| Type: | Herbal medicine |
| DrugBank ID: | DB10344 |
| DrugBank Description: | Ginger allergenic extract is used in allergenic testing. |
| PubChem ID: | 6850776 |
| CasNo: | 91770-91-1, 91770-92-2 |
| Repositioning for NAFLD: | Yes |
| SMILES: | O=C(CC(CCCCC)C)CCc1cc(OC)c(O)cc1.O=C(CCc1cc(OC)c(O)cc1)/C=C/CCCCC |
| Structure: |
|
| InChiKey: | QCVRFSPGUWEKFC-ILHSMLOTSA-N |
| Molecular Weight: | 568.795 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Antiallergic drug |
| Clinical Trial Progress: | Phase 2&3 completed (NCT02535195) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0121 | NCT02289235 | Early Phase 1 | Completed | No Results Available | May 1, 2019 | October 20, 2020 | Details |
| L0508 | IRCT20140307016876N3 | Phase 3 | Recruiting | No Results Available | 25/02/2018 | 26 March 2018 | Details |
| L0702 | IRCT20181111041611N3 | Phase 3 | Not Recruiting | No Results Available | 02/05/2020 | 18 May 2020 | Details |
| L0846 | IRCT2016042827652N1 | Phase 3 | Not Recruiting | No Results Available | 04/05/2016 | 22 February 2018 | Details |
| L0868 | NCT02535195 | Phase 2/Phase 3 | Not recruiting | No Results Available | 24/08/2015 | 7 September 2015 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00288 | 35152443 | J Food Sci | Bentong ginger oleoresin mitigates liver injury and modulates gut microbiota in mouse with nonalcoholic fatty liver disease induced by high-fat diet. | Details |
| A03079 | 34139323 | Cell Mol Gastroenterol Hepatol | 6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 Cascade. | Details |
| A03796 | 33861449 | Adv Exp Med Biol | Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease. | Details |
| A03797 | 33861444 | Adv Exp Med Biol | Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review. | Details |
| A05184 | 33343673 | Evid Based Complement Alternat Med | Investigation of the Synergistic Effect of Brown Sugar, Longan, Ginger, and Jujube (Brown Sugar Longan Ginger Tea) on Antioxidation and Anti-Inflammation in In Vitro Models. | Details |
| A08308 | 32158249 | Clin Exp Gastroenterol | Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | Details |
| A12530 | 30408433 | Toxicol Appl Pharmacol | 6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. | Details |
| A18466 | 27110262 | Hepat Mon | Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. | Details |
| A18583 | 27046953 | Yonago Acta Med | Components of Boiogito Suppress the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats. | Details |
| A18856 | 26900108 | J Agric Food Chem | Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | Details |
| A20491 | 25925967 | Phytomedicine | [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis. | Details |
| A20894 | 25658238 | Nutrients | 6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism. | Details |
| A25976 | 21246004 | World J Gastroenterol | Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. | Details |
| A42246 | 35106852 | Phytother Res | A systematic review and meta-analysis of preclinical and clinical studies on the efficacy of ginger for the treatment of fatty liver disease. | Details |
| A47016 | 29852391 | Biomed Pharmacother | Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol-induced liver dysfunction: Rescue effect of ginger extract. | Details |
| A47175 | 24171385 | J Agric Food Chem | Metabolomics of ginger essential oil against alcoholic fatty liver in mice. | Details |
| A49844 | 35623903 | Phytother Res | Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta-analyses of randomized controlled trials in humans. | Details |
| A50566 | 35338494 | J Food Biochem | Zingerone ameliorates non-alcoholic fatty liver disease in rats by activating AMPK. | Details |
| A51939 | 33073617 | Nutr Cancer | Herbal and Natural Dietary Products: Upcoming Therapeutic Approach for Prevention and Treatment of Hepatocellular Carcinoma. | Details |