Investigational Drug Details
| Drug ID: | D152 |
| Drug Name: | Ginseng |
| Synonyms: | Aralia ginseng root; Asian ginseng root; Chinese ginseng root; Ginseng (panax ginseng); Ginseng extract; Ginseng, asian; Hong shen root; Insam root; Korean ginseng; Korean ginseng root; Ninjin root; Panax ginseng; Panax ginseng root; Panax ginseng root extract; Panax schinseng root; Panax verus root; Red ginseng; Ren seng root; Ren shen; Ren shen root; True ginseng root; Ginseng Powder |
| Type: | Herbal medicine |
| DrugBank ID: | DB01404 |
| DrugBank Description: | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. |
| PubChem ID: | -- |
| CasNo: | 50647-08-0 |
| Repositioning for NAFLD: | Yes |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | Interleukin-6 antagonist; Prostaglandin G/H synthase 2 inhibitor; Aryl hydrocarbon receptor agonist |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | AHR agonist |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial completed (NCT03260543: Our results suggest that GBCK25 supplementation has beneficial effects on liver function.) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0748 | NCT03945123 | Not applicable | Not recruiting | No Results Available | 03/05/2019 | 12 December 2020 | Details |
| L0824 | NCT03260543 | Not applicable | Not recruiting | No Results Available | 23/03/2017 | 12 December 2020 | Details |
| L0886 | NCT02331589 | Phase 4 | Not recruiting | Has Results | 31/12/2014 | 19 October 2017 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00223 | 35178098 | Evid Based Complement Alternat Med | A Network Pharmacology Study on the Active Components and Targets of the Radix Ginseng and Radix Bupleuri Herb Pair for Treating Nonalcoholic Fatty Liver Disease. | Details |
| A00850 | 34948230 | Int J Mol Sci | It Is High Time Physicians Thought of Natural Products for Alleviating NAFLD. Is There Sufficient Evidence to Use Them? | Details |
| A03087 | 34136174 | Food Sci Nutr | Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice. | Details |
| A03377 | 34025131 | J Ginseng Res | Effect of Korean Red Ginseng on metabolic syndrome. | Details |
| A03796 | 33861449 | Adv Exp Med Biol | Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease. | Details |
| A03862 | 33841012 | J Ginseng Res | Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function. | Details |
| A03903 | 33824675 | Evid Based Complement Alternat Med | Jian-Gan-Xiao-Zhi Decoction Alleviates Inflammatory Response in Nonalcoholic Fatty Liver Disease Model Rats through Modulating Gut Microbiota. | Details |
| A03959 | 33807927 | Nutrients | Ginseng Saponin Enriched in Rh1 and Rg2 Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Inflammasome Activation. | Details |
| A04278 | 33679403 | Front Pharmacol | Ginsenosides Improve Nonalcoholic Fatty Liver Disease via Integrated Regulation of Gut Microbiota, Inflammation and Energy Homeostasis. | Details |
| A04345 | 33656663 | Hepatol Int | Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease. | Details |
| A05000 | 33419084 | Antioxidants (Basel) | Antioxidant and Anti-Inflammatory Effects of Korean Black Ginseng Extract through ER Stress Pathway. | Details |
| A05079 | 33385408 | Life Sci | Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease. | Details |
| A07454 | 32489856 | Integr Med Res | Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease. | Details |
| A07578 | 32437790 | Life Sci | Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. | Details |
| A07699 | 32387461 | J Ethnopharmacol | Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress. | Details |
| A08299 | 32161549 | Front Pharmacol | Relationship Between Ginsenoside Rg3 and Metabolic Syndrome. | Details |
| A08338 | 32148418 | J Ginseng Res | Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/high-fructose diet-fed mice. | Details |
| A08339 | 32148405 | J Ginseng Res | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice. | Details |
| A09072 | 31884405 | Phytomedicine | Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2/HO-1 antioxidant signaling pathway. | Details |
| A09253 | 31817227 | Nutrients | Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1. | Details |