Investigational Drug Details
| Drug ID: | D016 |
| Drug Name: | Artichoke |
| Synonyms: | Artichoke Leaf Extract; Cynara Scolymus L. |
| Type: | Biological extract |
| DrugBank ID: | DB10638 |
| DrugBank Description: | Artichoke allergenic extract is used in allergenic testing. |
| PubChem ID: | -- |
| CasNo: | 84012-14-6 |
| Repositioning for NAFLD: | Yes |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 on-going (IRCT20130126012278N3) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0626 | IRCT2014070218321N1 | Not applicable | Not Recruiting | No Results Available | 04/08/2014 | 22 February 2018 | Details |
| L0799 | IRCT20130126012278N3 | Phase 2 | Not Recruiting | No Results Available | 21/02/2018 | 26 March 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00207 | 35186807 | Can J Gastroenterol Hepatol | Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. | Details |
| A01847 | 34591699 | J Med Food | Artichoke Extract Directly Suppresses Inflammation and Apoptosis in Hepatocytes During the Development of Non-Alcoholic Fatty Liver Disease. | Details |
| A02006 | 34533249 | Phytother Res | The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial. | Details |
| A02408 | 34383355 | Int J Clin Pract | The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis. | Details |
| A04890 | 33465383 | Complement Ther Med | Effects of artichoke on blood pressure: A systematic review and meta-analysis. | Details |
| A07601 | 32429274 | Nutrients | The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. | Details |
| A13262 | 30060507 | Nutrients | Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity. | Details |
| A14217 | 29520889 | Phytother Res | Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. | Details |
| A14319 | 29469041 | Ann Hepatol | Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype. | Details |
| A17580 | 27735918 | Ter Arkh | [Nonalcoholic steatohepatitis and biliary sludge in people with metabolic syndrome]. | Details |
| A21909 | 24968200 | Br J Nutr | Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats. | Details |
| A32845 | 27293900 | Int J Hepatol | The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. | Details |
| A49400 | 35763310 | J Med Food | Therapeutic Potential of Artichoke in the Treatment of Fatty Liver: A Systematic Review and Meta-Analysis. | Details |
| A49807 | 35631240 | Nutrients | Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study. | Details |