Investigational Drug Details
| Drug ID: | D178 |
| Drug Name: | Hydroxytyrosol |
| Synonyms: | HXT |
| Type: | Chemical drug |
| DrugBank ID: | DB12771 |
| DrugBank Description: | Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer. |
| PubChem ID: | 82755 |
| CasNo: | 10597-60-1 |
| Repositioning for NAFLD: | No |
| SMILES: | C(CO)c1cc(O)c(cc1)O |
| Structure: |
|
| InChiKey: | JUUBCHWRXWPFFH-UHFFFAOYSA-N |
| Molecular Weight: | 154.165 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Antioxidant |
| Clinical Trial Progress: | Phase 3 completed (NCT02842567: The treatment with HXT and VitE reduced the NAFLD-related systemic inflammation in children, mainly by an increase of IL-10 circulating levels that occurred in response to DNA damage recovery, ultimately improving steatosis and hypertriglyceridemia.) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0577 | NCT02842567 | Phase 3 | Not recruiting | No Results Available | 13/07/2016 | 12 December 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A02031 | 34525916 | Curr Med Chem | Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects. | Details |
| A03578 | 33947572 | Mater Sci Eng C Mater Biol Appl | Nano-encapsulation of hydroxytyrosol into formulated nanogels improves therapeutic effects against hepatic steatosis: An in vitro study. | Details |
| A05964 | 33060043 | Dig Liver Dis | Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD. | Details |
| A06410 | 32889748 | Biotechnol Bioeng | Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip study. | Details |
| A07109 | 32620521 | Dig Liver Dis | Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration. | Details |
| A08523 | 32075238 | Nutrients | Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View. | Details |
| A10073 | 31501836 | Food Funct | High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration. | Details |
| A12134 | 30588836 | Antioxid Redox Signal | The Antioxidant Effects of Hydroxytyrosol and Vitamin E on Pediatric Nonalcoholic Fatty Liver Disease, in a Clinical Trial: A New Treatment? | Details |
| A13069 | 30153476 | Free Radic Biol Med | Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. | Details |
| A13271 | 30057681 | Oxid Med Cell Longev | Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT. | Details |
| A13805 | 29747118 | J Nutr Biochem | Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice. | Details |
| A14984 | 29141573 | Endocr Metab Immune Disord Drug Targets | Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection. | Details |
| A16429 | 28395666 | Lipids Health Dis | Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. | Details |
| A16442 | 28386616 | Food Funct | Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. | Details |
| A16591 | 28294699 | J Med Food | Chia Oil-Enriched Restructured Pork Effects on Oxidative and Inflammatory Status of Aged Rats Fed High Cholesterol/High Fat Diets. | Details |
| A18654 | 27012627 | J Nutr Biochem | Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | Details |
| A19039 | 26807847 | PLoS One | Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets. | Details |
| A49840 | 35624756 | Antioxidants (Basel) | Hydroxytyrosol Promotes the Mitochondrial Function through Activating Mitophagy. | Details |
| A50066 | 35537354 | Prostaglandins Leukot Essent Fatty Acids | Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver disease. | Details |