Investigational Drug Details
Drug ID: | D186 |
Drug Name: | ION 224 |
Synonyms: | ISIS-DGAT2Rx; ION-224; IONIS-DGAT2Rx; ISIS 484137 |
Type: | Miscellany |
DrugBank ID: | -- |
DrugBank Description: | -- |
PubChem ID: | -- |
CasNo: | -- |
Repositioning for NAFLD: | No |
SMILES: | -- |
InChiKey: | -- |
Molecular Weight: | -- |
DrugBank Targets: | -- |
DrugBank MoA: | -- |
DrugBank Pharmacology: | -- |
DrugBank Indication: | -- |
Targets: | DGAT2 inhibitor |
Therapeutic Category: | Enhance lipid metabolism |
Clinical Trial Progress: | Phase 2 on-going (NCT04932512: ION 224 is still in clinical trials for Non-alcoholic steatohepatitis in the US, Canada, the UK, Poland, and Hungary) |
Latest Progress: | Under clinical trials |

Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
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Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
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S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
Article ID | PMID | Source | Title |
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