Investigational Drug Details
| Drug ID: | D221 |
| Drug Name: | MEDI0382 |
| Synonyms: | Cotadutide |
| Type: | Chemical drug |
| DrugBank ID: | DB15194 |
| DrugBank Description: | Cotadutide is under investigation in clinical trial NCT03444584 (Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Subject With Type 2 Diabetes). |
| PubChem ID: | 134694273 |
| CasNo: | 1686108-82-6 |
| Repositioning for NAFLD: | No |
| SMILES: | O=C(N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1nc[nH]c1)CO)CCC(=O)N)[C@H](O)C)Cc1ccccc1)[C@H](O)C)CO)CC(=O)O)CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(=O)O)CO)CCC(=O)O)Cc1ccc(O)cc1)CC(C)C)CC(=O)O)CO)CCC(=O)O)CCCNC(=N)N)C)CCCNC(=N)N)CC(=O)O)Cc1ccccc1)C(C)C)C)Cc1c2c([nH]c1)cccc2 |
| Structure: |
|
| InChiKey: | YEKUUBPJRPXMBM-PTCFZACGSA-N |
| Molecular Weight: | 3728.092 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | GLP1R inhibitor; GCGR inhibitor |
| Therapeutic Category: | Improve insulin resistance |
| Clinical Trial Progress: | Phase 2 completed (NCT04019561) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0072 | NCT04019561 | Phase 2 | Completed | No Results Available | September 23, 2019 | May 27, 2021 | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A29839 | 33422984 | Eur J Med Chem | Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists. | Details |
| A48746 | 29926478 | Br J Clin Pharmacol | MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study. | Details |