Investigational Drug Details
| Drug ID: | D224 |
| Drug Name: | Metadoxine |
| Synonyms: | Pyridoxine mixture with Pyrrolidonecarboxylic Acid; Pyridoxine pyroglutamate |
| Type: | Chemical drug |
| DrugBank ID: | DB16554 |
| DrugBank Description: | -- |
| PubChem ID: | 115198 |
| CasNo: | 74536-44-0 |
| Repositioning for NAFLD: | No |
| SMILES: | C(=O)(O)[C@H]1NC(=O)CC1.C(O)c1c(CO)cnc(c1O)C |
| Structure: |
|
| InChiKey: | RYKKQQUKJJGFMN-HVDRVSQOSA-N |
| Molecular Weight: | 298.295 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Antialcoholic drug |
| Clinical Trial Progress: | Phase 3 suspended (NCT02541045: lack of resources to finance the project) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0265 | NCT02051842 | Phase 4 | Unknown status | No Results Available | January 2016 | January 31, 2019 | Details |
| L0867 | NCT02541045 | Phase 3 | Not recruiting | No Results Available | 31/08/2015 | 7 September 2021 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A12660 | 30341231 | Postgrad Med J | Pharmacological interventions for non-alcoholic fatty liver disease: a systematic review and network meta-analysis. | Details |
| A20754 | 25755546 | J Clin Exp Hepatol | Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial. | Details |
| A28109 | 16398154 | Orv Hetil | [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]. | Details |
| A28443 | 14708419 | J Int Med Res | A new approach to drug therapy in non-alcoholic steatohepatitis (NASH). | Details |
| A47355 | 12940921 | Aliment Pharmacol Ther | Review article: Nutritional therapy in alcoholic liver disease. | Details |
| A48832 | 27148681 | Minerva Med | Treatment of alcohol use disorder patients affected by liver cirrhosis and/or hepatocellular carcinoma awaiting liver transplantation. | Details |