Investigational Drug Details
| Drug ID: | D235 |
| Drug Name: | N-acetyl cysteine |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 12035 |
| CasNo: | 7218-04-4 |
| Repositioning for NAFLD: | Yes |
| SMILES: | C(NC(=O)C)(C(=O)O)CS |
| Structure: |
|
| InChiKey: | PWKSKIMOESPYIA-UHFFFAOYSA-N |
| Molecular Weight: | 163.198 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | SLC7A11 activator; GSS stimulator |
| Therapeutic Category: | Antiviral |
| Clinical Trial Progress: | Phase 2 on-going (NCT02117700) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0902 | NCT02117700 | Phase 2 | Not recruiting | No Results Available | 16/04/2014 | 12 December 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01852 | 34588976 | Front Pharmacol | N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function. | Details |
| A05207 | 33339155 | Antioxidants (Basel) | N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. | Details |
| A11877 | 30700851 | Lab Invest | Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis. | Details |
| A12067 | 30617744 | Pflugers Arch | Ablation of catalase promotes non-alcoholic fatty liver via oxidative stress and mitochondrial dysfunction in diet-induced obese mice. | Details |
| A16601 | 28288414 | Redox Biol | Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. | Details |
| A20884 | 25665792 | Am J Pathol | Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway. | Details |
| A22820 | 24286856 | Metabolism | Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. | Details |
| A24113 | 23218652 | Gastroenterol Hepatol | [Acute liver failure after bariatric surgery. A case report and literature review]. | Details |
| A28339 | 15598336 | Pediatr Transplant | Non-alcoholic steatohepatitis in children. | Details |
| A34160 | 24273738 | Redox Biol | Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. | Details |
| A34789 | 22592920 | Am J Respir Cell Mol Biol | Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. | Details |
| A47039 | 28492308 | Anal Chem | Visualizing the Conversion Process of Alcohol-Induced Fatty Liver to Steatohepatitis in Vivo with a Fluorescent Nanoprobe. | Details |
| A49109 | 17340120 | Arch Toxicol | Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression. | Details |
| A49883 | 35609854 | J Nutr Biochem | Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes. | Details |