Investigational Drug Details
| Drug ID: | D242 |
| Drug Name: | Nigella Sativa |
| Synonyms: | -- |
| Type: | Biological extract |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 90064-32-7 |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Gastrointestinal drug |
| Clinical Trial Progress: | Phase 2 on-going (IRCT2017012232109N1) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0491 | IRCT20100524004010N25 | Not applicable | Not Recruiting | No Results Available | 24/07/2018 | 25 February 2019 | Details |
| L0796 | IRCT20090804002288N13 | Not applicable | Not Recruiting | No Results Available | 06/06/2018 | 16 July 2018 | Details |
| L0826 | IRCT2017012232109N1 | Phase 2 | Not Recruiting | No Results Available | 12/03/2017 | 22 February 2018 | Details |
| L0890 | NCT02307344 | Not applicable | Not recruiting | No Results Available | 03/11/2014 | 19 February 2015 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01107 | 34867384 | Front Pharmacol | Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review. | Details |
| A04173 | 33728708 | Phytother Res | Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. | Details |
| A04610 | 33564654 | Clin Nutr Res | The Effects of Nigella sativa Supplementation on Liver Enzymes Levels: a Systematic Review and Meta-analysis of Randomized Controlled Trials. | Details |
| A09045 | 31890671 | J Diabetes Metab Disord | The effect of Nigella sativa oil on serum levels of inflammatory markers, liver enzymes, lipid profile, insulin and fasting blood sugar in patients with non-alcoholic fatty liver. | Details |
| A09651 | 31658321 | Rom J Morphol Embryol | Thymoquinone reverses nonalcoholic fatty liver disease (NAFLD) associated with experimental hypothyroidism. | Details |
| A10549 | 31293021 | Phytother Res | The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial. | Details |
| A10916 | 31126557 | Complement Ther Med | Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Results from a randomized, double-blind, placebo-controlled, clinical trial. | Details |
| A12025 | 30639231 | J Ethnopharmacol | Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial. | Details |
| A15142 | 29076670 | J Ayub Med Coll Abbottabad | Effects of nigella sativa on various parameters in Patients of non-alcoholic fatty liver disease. | Details |
| A18994 | 26826811 | Pak J Pharm Sci | Counter effects of N. Sativa L. and P. ovate L. on indicative markers of non alcoholic fatty liver disease. | Details |
| A20877 | 25670619 | Arab J Gastroenterol | Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats. | Details |
| A25071 | 22196506 | J Acupunct Meridian Stud | Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet. | Details |
| A49997 | 35567872 | Complement Ther Clin Pract | The effect of nigella sativa supplementation on cardiometabolic outcomes in patients with non-alcoholic fatty liver: A randomized double-blind, placebo-controlled trial. | Details |
| A51630 | 35483558 | Biochim Biophys Acta Mol Cell Biol Lipids | The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells. | Details |
| A51996 | 32512788 | Antioxidants (Basel) | Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. | Details |