Investigational Drug Details
| Drug ID: | D252 |
| Drug Name: | Oleanolic Acid |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 10494 |
| CasNo: | 508-02-1 |
| Repositioning for NAFLD: | No |
| SMILES: | C[C@]12[C@@]3(C)C(=CC[C@@H]1[C@]1(C)[C@@H](CC2)C(C)(C)[C@H](CC1)O)[C@H]1[C@](CC3)(C(=O)O)CCC(C1)(C)C |
| Structure: |
|
| InChiKey: | MIJYXULNPSFWEK-GTOFXWBISA-N |
| Molecular Weight: | 456.711 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 4 on-going (ChiCTR1900021568) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0477 | ChiCTR1900021568 | Phase 4 | Recruiting | No Results Available | 27/02/2019 | 4 March 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01379 | 34768813 | Int J Mol Sci | The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. | Details |
| A02352 | 34406209 | Braz J Med Biol Res | α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. | Details |
| A02766 | 34251802 | J Agric Food Chem | Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis. | Details |
| A06283 | 32942773 | Molecules | New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells. | Details |
| A09182 | 31846369 | Am J Physiol Endocrinol Metab | Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet. | Details |
| A09734 | 31632109 | Diabetes Metab Syndr Obes | Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model. | Details |
| A12646 | 30351048 | J Agric Food Chem | Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis. | Details |
| A13237 | 30070430 | Mol Nutr Food Res | Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet-Induced Obese Mice. | Details |
| A13721 | 29792584 | J Dev Orig Health Dis | Neonatal intake of oleanolic acid attenuates the subsequent development of high fructose diet-induced non-alcoholic fatty liver disease in rats. | Details |
| A14575 | 29345253 | Acta Pharmacol Sin | 3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways. | Details |
| A17492 | 27765368 | Phytomedicine | The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. | Details |
| A20896 | 25655997 | J Ethnopharmacol | Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice. | Details |
| A42713 | 33666565 | J Mol Endocrinol | Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPARγ-FABP4/aP2 pathway. | Details |
| A45415 | 24740831 | Mol Nutr Food Res | The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications. | Details |
| A48354 | 15570868 | Nihon Shokakibyo Gakkai Zasshi | [Treatment of nonalcoholic steatohepatitis (NASH)]. | Details |
| A49615 | 35691075 | Phytomedicine | Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. | Details |
| A50810 | 35218717 | Eur J Pharmacol | HA-20 prevents hepatocyte steatosis in metabolic-associated fatty liver disease via regulating Ca2+ relative signalling pathways. | Details |