Investigational Drug Details
| Drug ID: | D254 |
| Drug Name: | Oligofructose |
| Synonyms: | -- |
| Type: | Supplement |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial completed (NCT03184376: Independent of other lifestyle changes, prebiotic supplementation reduced histologically-confirmed steatosis in patients with NASH. Larger follow-up studies are warranted.) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0819 | NCT03184376 | Not applicable | Not recruiting | No Results Available | 08/06/2017 | 16 December 2017 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A05614 | 33187278 | Nutrients | The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | Details |
| A05628 | 33183606 | Carbohydr Polym | Friend or foe? The roles of inulin-type fructans. | Details |
| A05981 | 33053631 | Nutrients | Microbiota, Fiber, and NAFLD: Is There Any Connection? | Details |
| A06423 | 32885440 | J Food Sci | Effects of probiotic and prebiotic supplementation on metabolic parameters, liver aminotransferases, and systemic inflammation in nonalcoholic fatty liver disease: A randomized clinical trial. | Details |
| A06984 | 32673798 | Mol Metab | Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis. | Details |
| A13744 | 29779170 | Eur J Nutr | Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial. | Details |
| A15465 | 28894517 | Middle East J Dig Dis | Effects of Probiotic and Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | Details |
| A20746 | 25759243 | Toxicol Appl Pharmacol | Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction. | Details |
| A23590 | 23653231 | Mol Nutr Food Res | Effects of raftilose on serum biochemistry and liver morphology in rats fed with normal or high-fat diet. | Details |
| A37399 | 15770222 | Eur J Clin Nutr | Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. | Details |
| A43873 | 30629464 | FASEB J | Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. | Details |